AnalyzeDirect Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI. Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging. J Nucl Med. February 2013;54(2):299-305.
Full Text – Open Access
Publication Date
February 2013
How Analyze was Used
“To facilitate the production of regional time–activity curves, the following regions of interest were manually defined on the MR atlas using Analyze 7.0 software (AnalyzeDirect): frontal cortex, striatum, hippocampus, thalamus, amygdala, and cerebellum.”
Keywords
Animals
Automation
Autoradiography/methods
Brain/metabolism/pathology/radionuclide imaging
Fluorine Radioisotopes/pharmacology
Kinetics
Ligands
Models, Chemical
Morphinans/chemistry/pharmacology
Positron-Emission Tomography (PET)/methods
Protein Binding
Rats
Receptors, Opioid/agonists
Regression Analysis
Tissue Distribution
Author Affiliation(s)
Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. (PJR, VF, FIA)
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. (PJR, YTH, DC, NS, TDF, JWD, FIA)
Laboratory for Molecular Imaging, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge,UK. (YTH, DJW, TDF)
ABX Advanced Biochemical Compounds, Biomedizinische Forschungsreagenzien GmbH, Radeberg, Germany. (JM)
Department of Psychology, University of Cambridge, Cambridge, UK. (DC, NS, JWD)
Department of Pharmacology, Division of Chemical Biology and Medicinal Chemistry and NIMH Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill, NC, US. (BLR)
Petsenteret Norsk Medisinsk Syklotronsenter AS, Oslo, and Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. (GH)
Department of Psychiatry, University of Cambridge, Cambridge, UK. (JWD)
ID# 247
Tags: Animals, Automation, Autoradiography/methods, Brain/metabolism/pathology/radionuclide imaging, Chemical Models, Fluorine Radioisotopes/pharmacology, Kinetics, Ligands, Morphinans/chemistry/pharmacology, Opioid Receptors /agonists, Positron-Emission Tomography (PET)/methods, Protein Binding, Rats, Regression Analysis, Tissue Distribution