AnalyzeDirect Nadine Schleicher1,2,3, Amelia J. Tomkins1,4,5, Marian Kampschulte6, Jean-Marc Hyvelin7, Catherine Botteron7, Martin Juenemann1,2, Mesut Yeniguen1,2, Gabriele A. Krombach6, Manfred Kaps2, Neil J. Spratt4,5,8, Tibo Gerriets1,2,9, Max Nedelmann10,11. Sonothrombolysis with BR38 Microbubbles Improves Microvascular Patency in a Rat Model of Stroke. PLoS One. April 14th, 2016.
Full Text – Open Access
Publication Date
April 2016
How Analyze was Used
“Regions of interest (ROI) were manually determined in the right and left hemispheres to encompass striatum and cortex using Analyze™ 9.0 (Biomedical Imaging Resource, Mayo Clinic, USA). These regions were chosen as they are the most commonly affected regions in this stroke model. ROI templates were applied to each scan that were equally sized for cortex or striatum and positioned equidistant from the midline in respective regions and hemispheres. The vascular volume fraction (VVF) of each hemisphere was the sum of the cortical and striatal ROIs for that hemisphere, and represented a fraction of the total vascular volume.”
Keywords
Ultrasound imaging
Hemorrhage
Histology
Reperfusion
Cerebral arteries
Ischemic stroke
Arteries
Stroke
Author Affiliation(s)
1Heart and Brain Research Group, Justus-Liebig-University, Giessen, Germany
2Department of Neurology, Justus-Liebig-University, Giessen, Germany
3Department of Cardiac Surgery, Kerckhoff Clinic, Bad Nauheim, Germany
4School of Biomedical Sciences & Pharmacy, University of Newcastle
5Hunter Medical Research Institute, Newcastle, NSW, Australia
6Department of Diagnostic and Interventional Radiology, Justus-Liebig-University, Giessen, Germany
7Bracco Suisse S.A., Plan-les-Ouates, Geneva, Switzerland
8Hunter New England Local Health District, New Lambton, NSW, Australia
9Department of Neurology, Buergerhospital Friedberg, Friedberg, Germany
10Sana Regio Klinkum, Pinneberg, Germany
11Department of Neurology, University Hospital Center Hamburg-Eppendorf, Hamburg, Germany