AnalyzeDirect Ballav M. Borah et al. Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor Scientific Reports.
Publication Date
December 11, 2020
How Analyze was Used
“MR images were reconstructed to an isotropic voxel size of 187 microns and normalized using agarose phantom signal intensities. Intratumoral signal intensities were sampled from regions of interest using commercially available software (Analyze 10.0, AnalyzeDirect, Overland Park KS) and increases in normalized tumor signal intensities were calculated by subtracting baseline values from post-injection data. Linear regression was applied to the changes in signal vs time post-injection to calculate the rates of accumulation (slope) and initial enhancement (intercept), extracting vascular permeability and fractional vascular volumes, respectively. To visualize these parameters, 3D datasets were first filtered with a 3 × 3 × 3 low pass filter and appended into a 4D dataset, and then linear regression was applied per voxel across the 4th dimension.”
Keywords
Brain Tumor, Cancer, Nanoscience, Sonodynamic therapy, Photodynamic therapy
Author Affiliation(s)
Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA
