AnalyzeDirect Zhu XY, Daghini E, Chade AR, Napoli C, Ritman EL, Lerman A, Lerman LO. Simvastatin prevents coronary microvascular remodeling in renovascular hypertensive pigs. J Am Soc Nephrol. April 2007;18(4):1209-1217.
Full Text – Open Access
Publication Date
April 2007
How Analyze was Used
“Using the Analyze software package …, the transmural myocardium was then tomographically divided into subepicardium (outer two thirds) and subendocardium (inner one third), as described previously [Rodriguez-Porcel et al. 2006, Zhu et al. 2004].”
Keywords
Animals
Coronary Vessels/drug effects/pathology
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
Hypertension, Renovascular/drug therapy/pathology
Microcirculation/drug effects
Neovascularization, Physiologic/drug effects
Simvastatin/therapeutic use
Swine
Tumor Necrosis Factor-alpha/pharmacology
Author Affiliation(s)
Department of Internal Medicine, Division of Hypertension and Nephrology, Mayo Clinic College of Medicine, Rochester, MN, US. (X-YZ, ED, ARC, LOL)
Department of Internal Medicine, Divsion of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, US. (AL, LOL)
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, US. (ELR)
Research Center of Excellence in Cardiovascular Diseases and Departments of General Pathology and Medicine, University of Naples, Naples, Italy. (CN)
Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University, Boston, MA, US. (CN)
ID# 1713
Tags: Animals, Coronary Vessels/drug effects/pathology, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Microcirculation/drug effects, Physiologic Neovascularization/drug effects, Renovascular Hypertension/drug therapy/pathology, Simvastatin/therapeutic use, Swine, Tumor Necrosis Factor-alpha/pharmacology