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Short-term effects of tolvaptan on renal function and volume in patients with autosomal dominant polycystic kidney disease

Irazabal MV, Torres VE, Hogan MC, Glockner J, King BF, Ofstie TG, Krasa HB, Ouyang J, Czerwiec FS. Short-term effects of tolvaptan on renal function and volume in patients with autosomal dominant polycystic kidney disease. Kidney Int. August 2011;80(3):295-301.

Full Text – Open Access

Publication Date
August 2011

How Analyze was Used
“Coronal T2-weighted images were used to outline both kidneys and total kidney volume (TKV) was calculated using the ANALYZE bioimaging software system.”

Keywords
Adult
Benzazepines/therapeutic use
Biological Markers/blood
Contrast Media/diagnostic use
Creatinine/blood
Diuresis/drug effects
Female
Glomerular Filtration Rate/drug effects
Hormone Antagonists/therapeutic use
Humans
Iothalamic Acid/diagnostic use
Kidney/drug effects/metabolism/pathology/physiopathology
Magnetic Resonance Imaging (MRI)
Male
Middle Aged
Minnesota
Organ Size
Polycystic Kidney, Autosomal Dominant/blood/drug
therapy/pathology/physiopathology
Potassium/blood
Receptors, Vasopressin/antagonists & inhibitors/metabolism
Renal Circulation/drug effects
Time Factors
Treatment Outcome
Uric Acid/blood
p-Aminohippuric Acid/diagnostic use

Author Affiliation(s)
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, US. (MVI, VET, MCH, TGO)

Department of Radiology, Mayo Clinic, Rochester, MN, US. (JG, BFK)

Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, MD, US. (HBK, JO, FSC)

ID# 858

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