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Thankamony A, Tossavainen PH, Sleigh A, Acerini C, Elleri D, Dalton RN, Jackson NC, Umpleby AM, Williams RM, Dunger DB. Short-term administration of pegvisomant improves hepatic insulin sensitivity and reduces soleus muscle intramyocellular lipid content in young adults with type 1 diabetes. J Clin Endocrinol Metab. February 2014;99(2):639-647.

Publication Date
February 2014

How Analyze was Used
“Cross-sectional areas of fat were calculated using a semiautomated method, incorporating a threshold map (Analyze 7.0…) with manual input to distinguish between the subcutaneous and visceral fat.”

Keywords
Cross-Over Studies
Diabetes Mellitus, Type 1/metabolism
Female
Human Growth Hormone/analogs & derivatives/pharmacology
Humans
Insulin/blood
Insulin Resistance
Insulin-Like Growth Factor I/metabolism
Lipid Metabolism/drug effects
Liver/drug effects/metabolism
Male
Muscle, Skeletal/drug effects/metabolism

Author Affiliation(s)
Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK. (AT, PHT, CA, DE, RMW, DBD)

Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK. (AS)

Department of Paediatrics, University of Oulu, 90029 OYS, Oulu, Finland. (PHT)

WellChild Laboratory, King’s College London, Evelina Children’s Hospital, London SE1 7EH, UK. (RND)

Diabetes and Metabolic Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, UK. (NCJ, AMU)

National Institute for Health Research Cambridge Comprehensive Biomedical Research Centre, Cambridge, CB2 0QQ, UK. (DBD)

ID# 378

Tags: Cross-Over Studies, Female, Human Growth Hormone/analogs & derivatives/pharmacology, Humans, Insulin Resistance, Insulin-Like Growth Factor I/metabolism, Insulin/blood, Lipid Metabolism/drug effects, Liver/drug effects/metabolism, Male, Skeletal Muscle/drug effects/metabolism, Type 1 Diabetes Mellitus/metabolism