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Regional pattern of hippocampus and corpus callosum atrophy in Alzheimer’s disease in relation to dementia severity: evidence for early neocortical degeneration

Teipel SJ, Bayer W, Alexander GE, Bokde ALW, Zebuhr Y, Teichberg D, Müller-Spahn F, Schapiro MB, Möller HJ, Rapoport SI, Hampel H. Regional pattern of hippocampus and corpus callosum atrophy in Alzheimer’s disease in relation to dementia severity: evidence for early neocortical degeneration. Neurobiol Aging. January 2003;24(1):85-94.

Publication Date
January 2003

How Analyze was Used
“Pre-processing and subsequent measurements were done using ANALYZE™ software … on an SGI workstation.”

Keywords
Aged
Aged, 80 and over
Alzheimer Disease/ pathology
Amygdala/pathology
Analysis of Variance
Area Under Curve
Atrophy/pathology
Case-Control Studies
Corpus Callosum/pathology
Disease Progression
Female
Hippocampus/pathology
Humans
Magnetic Resonance Imaging (MRI)
Male
Matched-Pair Analysis
Middle Aged
Neocortex/pathology
Nerve Degeneration/pathology/physiopathology
Neuropsychological Tests
ROC Curve
Reference Values
Severity of Illness Index

Author Affiliation(s)
Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstr. 7, 80336 Munich, Germany. (SJT, WB, ALWB, YZ, HJM, HH)

MRI Morphology Core, Arizona Alzheimer’s Disease Research Center and Department of Psychology, Arizona State University, Tempe, AZ, US. (GEA)

Section on Brain Physiology and Metabolism, National Institute on Aging, National Institutes of Health, Bethesda, MD, US. (DT, SIR)

Department of Psychiatry, University of Basel, Basel, Switzerland. (FMS)

Department of Pediatric Neurology, Children Hospital Medical Center, Cincinatti, OH, US. (MBS)

ID# 2416

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