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Krishnan KR, Charles HC, Doraiswamy PM, Mintzer J, Weisler R, Yu X, Perdomo C, Ieni JR, Rogers S. Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer’s disease. Am J Psychiatry. November 2003;160(11):2003-2011.

Full Text – Open Access

Publication Date
November 2003

How Analyze was Used
“Segmentation was performed by using the Region of Interest module within the Analyze 2.5 software package [Styner et al. 2002].”

Keywords
Aged
Alzheimer Disease/diagnosis/drug therapy/psychology
Aspartic Acid/analogs & derivatives/analysis
Biological Markers/analysis
Brain Chemistry/drug effects
Cholinesterase Inhibitors/pharmacology/therapeutic use
Double-Blind Method
Female
Hippocampus/anatomy & histology/drug effects
Humans
Indans/pharmacology/therapeutic use
Inositol/analysis
Magnetic Resonance Spectroscopy
Male
Neurons/chemistry
Piperidines/pharmacology/therapeutic use
Placebos
Psychiatric Status Rating Scales
Severity of Illness Index
Treatment Outcome

Author Affiliation(s)
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, US.

ID# 2688

Tags: Aged, Alzheimer Disease/diagnosis/drug therapy/psychology, Aspartic Acid/analogs & derivatives/analysis, Biological Markers/analysis, Brain Chemistry/drug effects, Cholinesterase Inhibitors/pharmacology/therapeutic use, Double-Blind Method, Female, Hippocampus/anatomy & histology/drug effects, Humans, Indans/pharmacology/therapeutic use, Inositol/analysis, Magnetic Resonance Spectroscopy, Male, Neurons/chemistry, Piperidines/pharmacology/therapeutic use, Placebos, Psychiatric Status Rating Scales, Severity of Illness Index, Treatment Outcome