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Preclinical Activity of the Vascular Disrupting Agent OXi4503 against Head and Neck Cancer

Katelyn D. Bothwell1,2, Margaret Folaron1,3, and Mukund Seshadri1,3,4. Preclinical Activity of the Vascular Disrupting Agent OXi4503 against Head and Neck Cancer. Cancers. January 7th, 2016.

Full Text – Open Access

Publication Date
January 2016

How Analyze was Used
“To quantify tumor necrosis, captured fit images were uploaded into Analyze software and specified regions of interest (ROI) were created to compare the overall tumor area and the regions of necrosis, which was then reported as percent tumor necrosis”

Keywords
Head and neck squamous cell carcinomas
Angiogenesis
Vascular disrupting agents
Bioluminescence imaging
Magnetic resonance imaging

Author Affiliation(s)
1 Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
2 College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA
3 Department of Molecular and Cellular Biophysics and Biochemistry, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
4 Department of Oral Medicine/Head and Neck Surgery, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

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