AnalyzeDirect Langer O, Bauer M, Hammers A, Karch R, Pataraia E, Koepp MJ, Abrahim A, Luurtsema G, Brunner M, Sunder-Plassmann R, Zimprich F, Joukhadar C, Gentzsch S, Dudczak R, Kletter K, Muller M, Baumgartner C. Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia. September 2007;48(9):1774-1784.
Full Text – Open Access
Publication Date
September 2007
How Analyze was Used
“For PET data analysis eight different temporal lobe VOIs (hippocampus, parahippocampal and ambient gyrus (PAHG), amygdala, medial and lateral anterior temporal lobe, lateral occipitotemporal (fusiform) gyrus, superior temporal gyrus, and middle together with inferior temporal gyrus), and one VOI in the parietal lobe (superior parietal gyrus) were outlined on MRI (Fig. 1) and sampled on the dynamic coregistered PET using Analyze AVW 7.0 software.”
Keywords
Adult
Age of Onset
Brain/metabolism/radionuclide imaging
Carbon Radioisotopes/diagnostic use
Drug Resistance
Epilepsies, Partial/drug therapy/metabolism/radionuclide imaging
Female
Functional Laterality/physiology
Hippocampus/metabolism/radionuclide imaging
Humans
Male
Middle Aged
Models, Biological
P-Glycoprotein/metabolism
Pilot Projects
Positron-Emission Tomography (PET)/statistics & numerical data
Radiopharmaceuticals/diagnostic use
Temporal Lobe/metabolism/radionuclide imaging
Tissue Distribution
Verapamil/diagnostic use
Author Affiliation(s)
Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Vienna, Austria. (OL, MBauer, AA, MBrunner, CJ, MM)
Department of Radiopharmaceuticals, Austrian Research Centers GmbH – ARC, Seibersdorf, Austria. (OL)
Division of Neuroscience, Faculty of Medicine, Imperial College, and MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK. (AH)
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK. (AH, MJK)
Department of Medical Computer Sciences, Medical University of Vienna, Vienna, Austria. (RK)
Department of Neurology, Medical University of Vienna, Vienna, Austria. (EP, FZ, CB)
Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands. (GL)
Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria. (RSP)
Department of Radiology, Division of Neuroradiology, Medical University of Vienna, Vienna, Austria. (SG)
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. (RD, KK)
ID# 1786
Tags: Adult, Age of Onset, Biological Models, Brain/metabolism/radionuclide imaging, Carbon Radioisotopes/diagnostic use, Drug Resistance, Female, Functional Laterality/physiology, Hippocampus/metabolism/radionuclide imaging, Humans, Male, Middle Aged, P-Glycoprotein/metabolism, Partial Epilepsies/drug therapy/metabolism/radionuclide imaging, Pilot Projects, Positron-Emission Tomography (PET)/statistics & numerical data, Radiopharmaceuticals/diagnostic use, Temporal Lobe/metabolism/radionuclide imaging, Tissue Distribution, Verapamil/diagnostic use