Analyze Publications Database

Parametric mapping using spectral analysis for 11C-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects

Zhen Fan et al. Parametric mapping using spectral analysis for 11C-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects. European Journal of Nuclear Medicine and Molecular Imaging.

Publication Date
March 9 2018

How Analyze was Used
“To evaluate the binding, MRI and brain atlas (83-region Hammersmith atlas) were spatially transformed into native PET space using SPM8, and Analyze 11.0 (AnalyzeDirect) was used to sample the regional mean tracer update in predefined ROI regions as described in our previous studies. The ROI regional mean uptake was sampled in the following regions: posterior cingulate, frontal, temporal, parietal, and occipital lobes. ROI analysis was also performed for medial temporal lobe, hippocampus, and thalamus.”

Keywords
Spectral analysis, 11C–PBR28, PET, MCI, Compartmental modelling, Logan graphic analysis

Author Affiliation(s)
Imperial College London, London, UK

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