AnalyzeDirect Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC. Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity. J Neurosci. May 2014;34(22):7663-7676.
Full Text – Open Access
Publication Date
May 2014
How Analyze was Used
“Regions-of-interest (ROIs) were delineated for each subject independently on a slice-by-slice basis by a single expert reviewer using Analyze 8.1… ROIs were drawn for the orbitofrontal cortex, ventrolateral prefrontal cortex, ventromedial caudate, caudate body, dorsolateral caudate, putamen, nucleus accumbens, amygdala, ventral hippocampus, and cerebellum.”
Keywords
Behavior
Caudate Nucleus
Dopamine
Orbitofrontal Cortex
Positron Emission Tomography (PET)
Schizophrenia
Author Affiliation(s)
Departments of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EB, UK. (HFC, GC, ACR)
Psychology, University of Cambridge, Cambridge CB2 3EB, UK. (RR, TWR)
Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK. (HFC, RNC, RR, SJS, GC, FIA. TWR, ACR)
Department of Psychiatry, University of Cambridge, Cambridge CB2 3EB, UK. (RNC)
Wolfson Brain Imaging Centre, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK. (YTH, TDF, SJS, VF, FIA)
Liaison Psychiatry Service, Cambridge and Peterborough NHS Foundation Trust, Cambridge CB2 0QQ, UK. (RNC)
ID# 145
Tags: Behavior, Caudate Nucleus, Dopamine, Orbitofrontal Cortex, Positron Emission Tomography (PET), Schizophrenia