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Non-invasive monitoring of BMP-2 retention and bone formation in composites for bone tissue engineering using SPECT/CT and scintillation probes

Kempen DHR, Yaszemski MJ, Heijink A, Hefferan TE, Creemers LB, Britson J, Maran A, Classic KL, Dhert WJA, Lu L. Non-invasive monitoring of BMP-2 retention and bone formation in composites for bone tissue engineering using SPECT/CT and scintillation probes. J Control Release. March 2009;134(3):169-176.

Full Text – Open Access

Publication Date
March 2009

How Analyze was Used
“Analysis of bone formation in the consecutive μCT images was performed using the Analyze software package.”

Keywords
Animals
Bone Morphogenetic Protein 2/administration &
dosage/pharmacokinetics/therapeutic use
Bone Regeneration/physiology
Femur/metabolism/pathology/radionuclide imaging
Fumarates/chemistry
Gelatin/chemistry
Humans
Hydrogels/chemistry
Iodine Radioisotopes
Lactic Acid/chemistry
Male
Polyglycolic Acid/chemistry
Polypropylenes/chemistry
Rats
Rats, Sprague-Dawley
Recombinant Proteins/administration & dosage/pharmacokinetics/therapeutic use
Tissue Engineering/methods
Tissue Scaffolds/chemistry
Tomography, Emission-Computed, Single-Photon

Author Affiliation(s)
Tissue Engineering and Biomaterials Laboratory, Departments of Orthopedic Surgery and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, US. (DHRK, MJY, AH, TEH, JB, AM, LL)

Department of Orthopedics, University Medical Center, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. (DHRK, LBC, WJAD)

Radiation Safety, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, US. (KLC)

ID# 1361

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