AnalyzeDirect Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton. Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS. Neurobiology of Disease.
Publication Date
December 4 2018
How Analyze was Used
“In-house image analysis software was written in C++ using Analyze AVW image processing functions (AnalyzeDirect Inc., KS, USA) to automatically segment the lung air space, including the alveolar tissue and airways.”
Keywords
SOD1, Amyotrophic lateral sclerosis, Muscle specific kinase (MuSK), Respiration, Diaphragm, Neuromuscular junction, Motor Neuron
Author Affiliation(s)
Departments of Neuroscience, Biomedical Imaging, Microchemistry, Proteomics, and Lipidomics, Pathology, Preclinical and Translational Pharmacokinetics, and Antibody Discovery, Genentech, South San Francisco, CA, USA
