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Microvascular disease precedes the decline in renal function in the streptozotocin-induced diabetic rat

Maric-Bilkan C, Flynn ER, Chade AR. Microvascular disease precedes the decline in renal function in the streptozotocin-induced diabetic rat. Am J Physiol Renal Physiol. February 2012;302(3):F308-315.

Full Text – Open Access

Publication Date
February 2012

How Analyze was Used
“Three-dimensional volume images were reconstructed using a filtered back-projection algorithm and displayed on a computer workstation by volume rendering for display and analysis of renal MV using the Analyze…software package.”

Keywords
Angiography/methods
Animals
Diabetes Mellitus, Experimental/pathology/physiopathology/radiography
Diabetic Angiopathies/pathology/physiopathology/radiography
Diabetic Nephropathies/pathology/physiopathology/radiography
Disease Progression
Glomerular Filtration Rate/physiology
Kidney/blood supply/pathology/radiography
Male
Matrix Metalloproteinase 2/metabolism
Microcirculation/physiology
Rats
Rats, Sprague-Dawley
Renal Circulation/physiology
Tissue Inhibitor of Metalloproteinase-1/metabolism
Vascular Endothelial Growth Factor A/metabolism
Vascular Endothelial Growth Factor Receptor-1/metabolism
Vascular Endothelial Growth Factor Receptor-2/metabolism
X-Ray Microtomography

Author Affiliation(s)
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, US. (CMB, ERF, ARC)

Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, MS, US. (CMB, ARC)

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, US. (ARC)

ID# 518

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