AnalyzeDirect Bauer M, Karch R, Zeitlinger M, Stanek J, Philippe C, Wadsak W, Mitterhauser M, Jäger W, Haslacher H, Müller M, Langer O. Interaction of 11C-tariquidar and 11C-elacridar with P-glycoprotein and breast cancer resistance protein at the human blood-brain barrier. J Nucl Med. August 2013;54(8):1181-1187.
Full Text – Open Access
Publication Date
August 2013
How Analyze was Used
“T1-weighted MR images, acquired with an Achieva 3.0-T scanner (Philips), and the corresponding PET data were processed with Analyze 8.0… and SPM5 … software.”
Keywords
11C-elacridar
11C-tariquidar
ATP-Binding Cassette Transporters/metabolism
Acridines/diagnostic use/metabolism
Adult
Blood-Brain Barrier/metabolism/radionuclide imaging
Breast Cancer Restance Protein
Carbon Radioisotopes/diagnostic use
Humans
Male
Neoplasm Proteins/metabolism
P-Glycoprotein/metabolism
Positron-Emission Tomography (PET)
Protein Binding
Quinolines/diagnostic use/metabolism
Tetrahydroisoquinolines/diagnostic use/metabolism
Author Affiliation(s)
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. (MB, MZ, JS, CP, MMüller)
Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria. (RK)
Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria. (JS)
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. (CP, WW, MMitterhauser, OL)
Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria. (WJ)
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. (HH)
ID# 384
Tags: 11C-elacridar, 11C-tariquidar, Acridines/diagnostic use/metabolism, Adult, ATP-Binding Cassette Transporters/metabolism, Blood-Brain Barrier/metabolism/radionuclide imaging, Breast Cancer Restance Protein, Carbon Radioisotopes/diagnostic use, Humans, Male, Neoplasm Proteins/metabolism, P-Glycoprotein/metabolism, Positron Emission Tomography (PET), Protein Binding, Quinolines/diagnostic use/metabolism, Tetrahydroisoquinolines/diagnostic use/metabolism