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Initial joint bleed volume in a delayed on‐demand treatment setup correlates with subsequent synovial changes in hemophilic mice

Kåre Kryger Vøls et al. Initial joint bleed volume in a delayed on‐demand treatment setup correlates with subsequent synovial changes in hemophilic mice. Animal Models and Experimental Medicine.

Publication Date
June 3, 2020

How Analyze was Used
“In order to quantify joint bleed volumes, the in vivo micro‐CT scans were divided into 2 objects (bone and contrast agent) by semi‐automatic threshold‐based image segmentation in image analysis software (Analyze 12.0; AnalyzeDirect). Then, the volume of the contrast agent was determined by automatic image sampling and used as surrogate for the bleed volume, as described.”

Keywords
Animal models, Arthropathy, Hemarthrosis, Haemophilia A, In vivo imaging, Micro‐CT

Author Affiliation(s)
University of Copenhagen, Frederiksberg, Denmark

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