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McGinnity CJ, Hammers A, Riano Barros DA, Luthra SK, Jones PA, Trigg W, Micallef C, Symms MR, Brooks DJ, Koepp MJ, Duncan JS. Initial evaluation of ¹⁸F-GE-179, a putative PET Tracer for activated N-methyl D-aspartate receptors. J Nucl Med. March 2014;55(3):423-430.

Full Text – Open Access

Publication Date
March 2014

How Analyze was Used
“Global (whole-brain) radioactivity concentration (i.e., uptake [KBq/mL]) in the summation images was computed using a whole-brain mask, which was created for each of the 9 participants from their 5- to 30-min summed images using the extract region tool implemented in Analyze 8.1 (AnalyzeDirect, Inc.); the mean over the entire matrix within this mask was then computed.”

Keywords
Adult
Brain/metabolism/radionuclide imaging
Female
Guanidines/chemistry/diagnostic use/metabolism
Humans
Kinetics
Ligands
Male
Middle Aged
Models, Biological
Positron-Emission Tomography/methods
Radioactive Tracers
Radiochemistry
Receptors, N-Methyl-D-Aspartate/metabolism
Cns 5161
Ge-179
Nmda

Author Affiliation(s)
Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. (CJM, AH, DARB, DJB)

MRC Clinical Sciences Centre, London, UK. (CJM, AH, DARB, MJK, JSD)

The Neurodis Foundation, CERMEP—Imagerie du Vivant, Lyon, France. (AH)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK. (AH, CM, MRS, MJK, JSD)

Epilepsy Society, Chalfont St. Peter, UK. (AH, CM, MRS, MJK, JSD)

GE Healthcare plc, Amersham, UK. (SKL, PAJ, WT, DJB)

ID# 37

Tags: Adult, Biological, Brain/metabolism/radionuclide imaging, Cns 5161, Female, Ge-179, Guanidines/chemistry/diagnostic use/metabolism, Humans, Kinetics, Ligands, Male, Middle Aged, Models, N-Methyl-D-Aspartate/metabolism, Nmda, Positron-Emission Tomography/methods, Radioactive Tracers, Radiochemistry, Receptors