AnalyzeDirect Olson JA, Jr., Budd GT, Carey LA, Harris LA, Esserman LJ, Fleming GF, Marcom PK, Leight GS, Jr., Giuntoli T, Commean P, Bae K, Luo J, Ellis MJ. Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial. J Am Coll Surg. May 2009;208(5):906-914; discussion 915-906.
Full Text – Open Access
Publication Date
May 2009
How Analyze was Used
“The cranial-caudal and medial-lateral oblique mammogram films, both pretreatment and 16 weeks posttreatment, were digitized and saved as Digital Imaging and Communications in Medicine (DICOM) files….The Digital Imaging and Communications in Medicine files were uploaded into the Analyze software system … for performing RECIST [Response Evaluation Criteria in Solid Tumors] measurements [Robb 2001]. An experienced radiologist (KB) measured the longest dimension of the lesion in the cranial-caudal and medial-lateral oblique views for pre- and posttreatment by using Image Edit (Analyze software tool) to define the perimeter of the lesion semiautomatically. In some patients, the program delineated the boundary well, but in other patients manual editing of the region was required to remove areas not identified as lesion or to add areas of lesion.”
Keywords
Aged
Aged, 80 and over
Aromatase Inhibitors/administration & dosage
Breast Neoplasms/drug therapy/pathology/surgery
Carcinoma, Ductal, Breast/drug therapy/pathology/surgery
Carcinoma, Lobular/drug therapy/pathology/surgery
Chemotherapy, Adjuvant
Female
Humans
Mastectomy, Segmental
Middle Aged
Multivariate Analysis
Neoadjuvant Therapy
Neoplasm Staging
Nitriles/administration & dosage
Treatment Outcome
Triazoles/administration & dosage
Author Affiliation(s)
Department of Surgery, Duke Comprehensive Cancer Center, Durham, NC, US. (JAO, GSL)
Department of Medicine, Duke Comprehensive Cancer Center, Durham, NC, US. (PKM)
Dana Farber Cancer Center, Boston, MA, US. (LAH)
Cleveland Clinic Taussig Cancer Center, Cleveland, OH, US. (GTB)
Lineberger Cancer Center, University of North Carolina, Durham, NC, US. (LAC)
University of California San Francisco and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, US. (LJE)
University of Chicago Cancer Research Center, Chicago, IL, US. (GFF)
Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO, US. (TG, MJE)
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, US. (PC, KB)
Department of Biostatistics, Washington University School of Medicine, St Louis, MO, US. (JL)
Siteman Comprehensive Cancer Center, St Louis, MO, US. (MJE)
ID# 1336
Tags: /drug therapy/pathology/surgery, Adjuvant Chemotherapy, Aged, Aged_80 and over, Aromatase Inhibitors/administration & dosage Breast Neoplasms/drug therapy/pathology/surgery, Ductal Breast Carcinoma, Female, Humans, Lobular Carcinoma/drug therapy/pathology/surgery, Middle Aged, Multivariate Analysis, Neoadjuvant Therapy, Neoplasm Staging, Nitriles/administration & dosage, Segmental Mastectomy, Treatment Outcome, Triazoles/administration & dosage