AnalyzeDirect Lingford-Hughes A, Hume SP, Feeney A, Hirani E, Osman S, Cunningham VJ, Pike VW, Brooks DJ, Nutt DJ. Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography. J Cereb Blood Flow Metab. July 2002;22(7):878-889.
Full Text – Open Access
Publication Date
July 2002
How Analyze was Used
“Reconstructed [11C]flumazenil and [11C]Ro15 4513 parametric images were analyzed on a Sun SPARC workstation … using AnalyzeAVW version 3.1 (… Robb and Hanson, 1991).”
Keywords
Animals
Azides/pharmacokinetics
Benzodiazepines/pharmacokinetics
Binding, Competitive
Carbon Radioisotopes/diagnostic use/pharmacokinetics
Cerebellum/metabolism
Cerebral Cortex/metabolism
Flumazenil/analogs & derivatives/diagnostic use/metabolism
Hippocampus/metabolism
Humans
Kinetics
Male
Rats
Rats, Sprague-Dawley
Receptors, GABA-A/analysis/metabolism
Tissue Distribution
Tomography, Emission-Computed
Author Affiliation(s)
Psychopharmacology Unit, School of Medical Science, University of Bristol, Bristol, UK. (ALH, AF, DJN)
MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK. (ALH, AF, VWP, DJB)
Imaging Research Solutions Ltd (formerly MRC Cyclotron Unit), Hammersmith Hospital, London, UK. (SPH, EH, SO, VJC, DJB)
ID# 2603
Tags: Animals, Azides/pharmacokinetics, Benzodiazepines/pharmacokinetics, Carbon Radioisotopes/diagnostic use/pharmacokinetics, Cerebellum/metabolism, Cerebral Cortex/metabolism, Competitive Binding, Emission-Computed Tomography, Flumazenil/analogs & derivatives/diagnostic use/metabolism, GABA-A Receptors/analysis/metabolism, Hippocampus/metabolism, Humans, Kinetics, Male, Rats, Sprague-Dawley Rats, Tissue Distribution