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Adams HP, Wagner S, Sobel DF, Slivka LS, Sipe JC, Romine JS, Beutler E, Koziol JA. Hypointense and hyperintense lesions on magnetic resonance imaging in secondary-progressive MS patients. Eur Neurol. July 1999;42(1):52-63.

Publication Date
July 1999

How Analyze was Used
“Lesion loads were quantified using a semiautomated technique (seed-growing) adapted from Wicks et al. … and Filippi et al. … by a single observer (HPA) as implemented in Analyze 5.0 … running on a Hewlett-Packard 712/60 workstation.”

Keywords
Adult
Cladribine/therapeutic use
Disability Evaluation
Disease Progression
Double-Blind Method
Female
Humans
Immunosuppressive Agents/therapeutic use
Magnetic Resonance Imaging (MRI)
Male
Middle Aged
Multiple Sclerosis/drug therapy/pathology/physiopathology
Neurologic Examination
Placebos
Treatment Outcome

Author Affiliation(s)
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, US. (HPA, SW, SLS, EB, JAK)

Department of Neurology, Ruprecht Karls University, Heidelberg, Germany. (SW)

Department of Radiology, Scripps Clinic, La Jolla, CA, US. (DFS)

Division of Neurology, Scripps Clinic, La Jolla, CA, US. (JCS, JSR)

ID# 2897

Tags: Adult, Cladribine/therapeutic use, Disability Evaluation, Disease Progression, Double-Blind Method, Female, Humans, Immunosuppressive Agents/therapeutic use, Magnetic Resonance Imaging (MRI), Male, Middle Aged, Multiple Sclerosis/drug therapy/pathology/physiopathology, Neurologic Examination, Placebos, Treatment Outcome