AnalyzeDirect Stokes PRA, Egerton A, Watson B, Reid A, Lappin J, Howes OD, Nutt DJ, Lingford-Hughes AR. History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability. J Psychopharmacol. January 2012;26(1):144-149.
Publication Date
January 2012
How Analyze was Used
“The deformed striatal atlas was used to sample counts from the add image using Analyze 8.0 software (www.analyzedirect.com). BP ND values, the ratio of specifically bound radioligand to that of the non-displaceable ligand in the cerebellar reference tissue…, were calculated for each striatal region as the ratio of striatal counts to cerebellar counts, minus 1, over the steady-state time period.”
Keywords
Adult
Alcohol Drinking/adverse effects
Cannabis
Carbon Isotopes/diagnostic use
Corpus Striatum/metabolism
Female
Humans
Limbic System/drug effects/metabolism
Male
Marijuana Abuse/metabolism
Nicotine/adverse effects
Positron-Emission Tomography (PET)
Psychotic Disorders/metabolism
Raclopride/diagnostic use
Receptors, Dopamine D2/metabolism
Receptors, Dopamine D3/metabolism
Synaptic Transmission/drug effects
Author Affiliation(s)
Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK. (PRAS, AE, JL, ODH)
Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Imperial College London, London, UK. (PRAS, BW, AR, DJN, ARLH)
Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, UK. (AE)
ID# 515
Tags: Adult, Alcohol Drinking/adverse effects, Cannabis, Carbon Isotopes/diagnostic use, Corpus Striatum/metabolism, Dopamine D2 Receptors/metabolism, Dopamine D3 Receptors/metabolism, Female, Humans, Limbic System/drug effects/metabolism, Male, Marijuana Abuse/metabolism, Nicotine/adverse effects, Positron Emission Tomography (PET), Psychotic Disorders/metabolism, Raclopride/diagnostic use, Synaptic Transmission/drug effects