Huiying Gu et al. Evaluation of chronic lead effects in the Blood Brain Barrier System by DCE-CT Journal of Trace Elements in Medicine and Biology.
September 19, 2020
How Analyze was Used
“Reconstructed and calibrated CT images were imported into Analyze 12 (AnalyzeDirect, Stilwell KS) and all image volumes were registered to the first volume using a normalized entropy mutual information algorithm. Using the image volume with peak contrast, images were segmented using a semi-automated thresholding technique to extract the whole brain volumes. To permit collection of the arterial input function, the left ventricle was manually segmented, taking care not to include the septum or free wall of the myocardium. Post segmentation, time courses for both brain and AIF were extracted using ROITool (AnalyzeDirect, Stilwell KS) and stored for subsequent modeling.”
Lead, Alzheimer’s disease, Beta amyloid, DCE-CT, Permeability, APP transgenic mice
Indiana University School of Medicine, Indianapolis, Indiana, USA