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Estimated maximal and current brain volume predict cognitive ability in old age

Royle NA, Booth T, Valdés Hernández MC, Penke L, Murray C, Gow AJ, Maniega SM, Starr J, Bastin ME, Deary IJ, Wardlaw JM. Estimated maximal and current brain volume predict cognitive ability in old age. Neurobiol Aging. December 2013;34(12):2726-2733.

Full Text – Open Access

Publication Date
December 2013

How Analyze was Used
“The ICV [intracranial volume], which includes brain tissue, cerebrospinal fluid (CSF), veins and dura, was obtained semi-automatically using the T2*W sequence, with the Object Extraction Tool in Analyze 9.0… providing an initial segmentation that was manually edited to remove erroneous structures.”

Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Aging/pathology/psychology
Brain/pathology/physiology/physiopathology
Brain volume
Child
Child Psychology
Cognition
Female
Forecasting
Humans
Intelligence Tests
IQ
Life Course Cognitive Ability
Magnetic Resonance Imaging (MRI)
Male
Middle Aged
Organ Size
Structural Brain Imaging Biomarkers
Young Adult

Author Affiliation(s)
Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK. (NAR, MCVH, SMM, MEB, JMW)

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. (NAR, TB, MCVH, LP, AJG, SMM, JS, MEB, IJD, JMW)

Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK. (NAR, MCVH, LP, SMM, MEB, JMW)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. (NAR, MCVH, LP, SMM, MEB, JMW)

Department of Psychology, University of Edinburgh, Edinburgh, UK. (TB, LP, CM, AJG, IJD)

Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK. (JS)

ID# 217

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