Enzymatic activity of free-prostate-specific antigen (f-PSA) is not required for some of its physiological activities

Chadha KC, Nair BB, Chakravarthi S, Zhou R, Godoy A, Mohler JL, Aalinkeel R, Schwartz SA, Smith GJ. Enzymatic activity of free-prostate-specific antigen (f-PSA) is not required for some of its physiological activities. Prostate. November 2011;71(15):1680-1690.

Publication Date
November 2011

How Analyze was Used
“Five images were taken per well. The images were processed further using Analyze 7.0 (AnalyzeDirect, Inc., Overland Park, KS) and Angioquant v1.33 37 to obtain the average tubule length for each image.”

Keywords
Cathepsin D/biosynthesis/genetics
Cell Line
Cell Movement/drug effects/physiology
Endothelial Cells/drug effects/enzymology
Fibroblast Growth Factor 2/metabolism
Focal Adhesion Kinase 1/biosynthesis/genetics
Gene Expression Regulation, Enzymologic
Humans
Male
Neovascularization, Physiologic
Nuclear Proteins/biosynthesis/genetics
Prostate/enzymology
Prostate-Specific Antigen/antagonists &
inhibitors/biosynthesis/genetics/metabolism
RNA, Messenger/biosynthesis/genetics
Reverse Transcriptase Polymerase Chain Reaction
Twist Transcription Factor/biosynthesis/genetics
Vascular Endothelial Growth Factor A/metabolism
Vascular Endothelial Growth Factor Receptor-1/biosynthesis/genetics
Vascular Endothelial Growth Factor Receptor-2/biosynthesis/genetics
Zinc/pharmacology

Author Affiliation(s)
Department of Molecular & Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, US. (KCC, BBN, SC, RZ)

Department of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo and Kaleida Health, Buffalo, NY, US. (BBN, RA, SAS)

Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, US. (AG, JLM, GJS)

ID# 665

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Enzymatic activity of free-prostate-specific antigen (f-PSA) is not required for some of its physiological activities