AnalyzeDirect Yuya Mizukami et al. Effects of plasminogen activator inhibitor-1 deficiency on bone disorders and sarcopenia caused by adenine-induced renal dysfunction in mice PLOS One.
Publication Date
October 10, 2024
How Analyze was Used
” Microstructural parameters of femurs were assessed using the visualization and analysis software, Analyze 14.0 (AnalyzeDirect, Inc., KS, USA). In the trabecular bone analysis, a 1-mm-thick region from the end of the growth plate was used, and the following parameters were assessed: trabecular bone mineral density (BMD), the bone volume fraction (BV/TV, the ratio of the segmented bone volume to the total volume of the region of interest), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp). In the cortical bone analysis, a 1-mm-thick region of the mid-diaphysis of the femur was used, and the following parameters were assessed: cortical tissue mineral density (CtTMD), cortical bone area (Ct.Ar), average cortical thickness (Ct.Th), cortical porosity (Ct.Po), total cross-sectional area inside the periosteal envelope (Tt.Ar), and the cortical area fraction (Ct.Ar/Tt.Ar).”
Keywords
Chronic kidney disease (CKD), CKD-mineral and bone disorder (MBD), Sarcopenia, Plasminogen activator inhibitor-1
Author Affiliation(s)
Kindai University, Osakasayama, Osaka, Japan
