AnalyzeDirect Gabriel Broocks et al. Effect of Intravenous Alteplase on Functional Outcome and Secondary Injury Volumes in Stroke Patients with Complete Endovascular Recanalization Journal of Clinical Medicine.
Publication Date
March 12, 2022
How Analyze was Used
“Image analyses including volumetric and densitometric analysis were performed using commercially available software (Analyze 11.0, Biomedical Imaging Resource, Mayo Clinic, Rochester, MN, USA) by a board-certified experienced neuroradiologist using standardized procedures. Ischemic lesion net water uptake (NWU) was measured as an imaging biomarker to quantify cerebral ischemic edema before treatment on admission CT and on follow-up CT (FCT) 24 h after treatment with a standardized procedure, as previously described in detail. NWU describes ischemic lesion water uptake per volume of brain infarct (i.e., relative proportion of edema). ΔNWU was defined as the additional NWU from admission to FCT for each patient (ΔNWU = NWUfct − NWUadmission). Total infarct volume has been defined as the volume of the whole visually evident lesion in FCT and was measured using semiautomatic volumetric segmentation. Edema volume (EV) as a measure of the absolute volume of edema was then determined as described before as the product of the total infarct volume and NWUfct according to Equation (1) according to Nawabi et al.
Equation (1):
Edema volume = Total infarct volume * % − NWU”
Keywords
Stroke, Thrombectomy, Thrombolysis
Author Affiliation(s)
University Medical Center Hamburg-Eppendorf, Hamburg, Germany
