AnalyzeDirect Coles JP, Cunningham AS, Salvador R, Chatfield DA, Carpenter A, Pickard JD, Menon DK. Early metabolic characteristics of lesion and nonlesion tissue after head injury. J Cereb Blood Flow Metab. May 2009;29(5):965-975.
Full Text – Open Access
Publication Date
May 2009
How Analyze was Used
“Without knowledge of the PET data, we constructed lesion ROIs, nonlesion ROIs, and control ROIs based on MR data. Areas of structural abnormality were identified on follow-up FLAIR imaging. Using the threshold tool in Analyze software these areas were outlined on all relevant slices and considered as one ROI. Where possible, these lesion ROIs were mirrored onto the contralateral hemisphere to produce corresponding nonlesion ROIs. Control ROIs of comparable size and regional location to patient ROIs were produced from control MR data. All ROIs were projected onto the corresponding coregistered PET imaging data (see Figure 1). Values for CBF, CMRO2, OEF, and CBV were determined for each ROI (for ROI-based analyses), and also for the entire population of voxels within each group of ROIs (for voxel-based analyses). To investigate regional inter- and intra-patient differences in pathophysiology, we analyzed relationships between physiologic variables at the voxel-based level. For the voxel-based analyses, for each individual contusion (ROI), we plotted summary curves for the relationships between the physiologic variables.”
Keywords
Adolescent
Adult
Brain/metabolism/pathology/radionuclide imaging
Brain Injuries/metabolism/pathology/physiopathology/radionuclide imaging
Cerebrovascular Circulation/physiology
Female
Glasgow Coma Scale
Humans
Magnetic Resonance Imaging (MRI)
Male
Oxygen Consumption/physiology
Oxygen Radioisotopes
Positron-Emission Tomography (PET)
Retrospective Studies
Time Factors
Young Adult
Author Affiliation(s)
Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (JPC, ASC, DAC, DKM)
Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (JPC, ASC, RS, DAC, AC, JDP, DKM)
Benito Menni, CASM and CIBERSAM, Dr. Antoni Pujadas, Barcelona, Spain. (RS)
Department of Neurosurgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (JDP)
ID# 1300
Tags: Adolescent, Adult, Brain Injuries/metabolism/pathology/physiopathology/radionuclide imaging, Brain/metabolism/pathology/radionuclide imaging, Cerebrovascular Circulation/physiology, Female, Glasgow Coma Scale, Humans, Magnetic Resonance Imaging (MRI), Male, Oxygen Consumption/physiology, Oxygen Radioisotopes, Positron Emission Tomography (PET), Retrospective Studies, Time Factors, Young Adult