AnalyzeDirect Bohnen NI, Kaufer DI, Hendrickson R, Ivanco LS, Lopresti BJ, Koeppe RA, Meltzer CC, Constantine G, Davis JG, Mathis CA, Dekosky ST, Moore RY. Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer’s disease. J Neurol Neurosurg Psychiatry. March 2005;76(3):315-319.
Full Text – Open Access
Publication Date
March 2005
How Analyze was Used
“The MR data were cropped in preparation for alignment with the PET data using AnalyzeAVW software… by setting all non-brain voxels to zero intensity.”
Keywords
Acetylcholinesterase/drug effects/ pharmacology
Aged
Aged, 80 and over
Alzheimer Disease/complications/drug therapy
Attention/drug effects
Cerebral Cortex/enzymology
Cholinesterase Inhibitors/pharmacology
Cognition Disorders/drug therapy/etiology
Female
Humans
Indans/pharmacology
Male
Piperidines/pharmacology
Positron-Emission Tomography (PET)
Author Affiliation(s)
Department of Neurology, University of Pittsburgh Medical School, Pittsburgh, PA, US. (NIB, DIK, RH, LSI, STD, RYM)
Department of Radiology, University of Pittsburgh Medical School, Pittsburgh, PA, US. (NIB, BJL, CCM, JGD, CAM)
VA Pittsburgh Healthcare system, Pittsburgh, PA, US. (NIB)
Department of Radiology, The University of Michigan, Ann Arbor, MI, US. (RAK)
Department of Mathematics and Statistics, University of Pittsburgh, Pittsburgh, PA, US. (GC)
ID# 2150
Tags: Acetylcholinesterase/drug effects/ pharmacology, Aged, Aged_80 and over, Alzheimer Disease/complications/drug therapy, Attention/drug effects, Cerebral Cortex/enzymology, Cholinesterase Inhibitors/pharmacology, Cognition Disorders/drug therapy/etiology, Female, Humans, Indans/pharmacology, Male, Piperidines/pharmacology, Positron Emission Tomography (PET)