AnalyzeDirect Jing Gao et al. Daphnetin Alleviates Senile and Disuse Osteoporosis by Distinct Modulations of Bone Formation and Resorption Antioxidants.
Publication Date
November 29, 2022
How Analyze was Used
“To determine the bone mineral density (BMD) and microarchitecture of bone, the left femurs of mice were scanned using a micro-CT scanner (Quantum GX, PerkinElmer, Antwerp, Belgium). After reconstruction, the micro-CT data were loaded into Analyze 12.0 software (AnalyzeDirect, Overland Park, KS, USA) for calculation. For cancellous bone analysis, trabecular BMD, bone volume fraction (BV/TV), bone surface/bone volume (BS/BV), trabecular thickness (Tb. Th), trabecular separation (Tb. Sp), and connection density were calculated from a 250-slice round region of the distal femur. For cortical bone analysis, cortical BMD, BV/TV, BS/BV, cortical bone thickness (Ct. Th), and cortical area fraction (Ct. Ar/Tt. Ar) were calculated from a 60-slice round region of the mid-diaphysis femur.”
Keywords
Daphnetin, Senile osteoporosis, Disuse osteoporosis, Osteoblast, Osteoclast, NADPH oxidase, Reactive oxygen species (ROS), Mitochondrial homeostasis
Author Affiliation(s)
Jiaotong University, Xi’an, China
