AnalyzeDirect Amandine Jullienne et al. Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease Frontiers in Aging Neuroscience.
Publication Date
July 17, 2023
How Analyze was Used
“All PET and MRI images were co-registered using a 9 degrees of freedom ridged-body mutual information-based normalized entropy algorithm (Studholme et al., 1998), and mapped to stereotactic mouse brain coordinates (Franklin and Paxinos, 2013) using Analyze 12 (AnalyzeDirect, Stilwell KS, RRID:SCR_005988). Post-registration, 56 bilateral brain regions were extracted, left and right regions averaged, and ratioed to the cerebellum yielding 27 unique specific uptake value ratios (SUVR) volumes of interest.”
Keywords
Alzheimer’s disease, Cerebrovasculature, PET, MRI, Sex, Blood–brain barrier, Vessels
Author Affiliation(s)
University of California, Irvine, California, USA
