AnalyzeDirect Adrian L. Oblak et al. Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study Frontiers in Aging Neuroscience.
Publication Date
July 22, 2021
How Analyze was Used
“All PET and MRI images were co-registered using a ridged-body mutual information-based normalized entropy algorithm with 9° of freedom and mapped to stereotactic mouse brain coordinates using Analyze 12 (AnalyzeDirect, Stilwell, KS, United States). Post-registration, 56 bilateral regions were extracted via brain atlas and averaged to yield 56 unique volumes of interest (27 bilateral regions) that map to the following key cognitive and motor centers: Agranular Insular Cortex; Auditory Cortex; Caudate Putamen; Cerebellum; Cingulate Cortex; Corpus Callosum; Dorsolateral Orbital Cortex; Dorsintermed Entorhinal Cortex; Dysgranular Insular Cortex; Ectorhinal Cortex; Fornix; Frontal Association Cortex; Hippocampus; Lateral Orbital Cortex; Medial Orbital Cortex; Parietal Cortex; Parietal Association Cortex; Perirhinal Cortex; Prelimbic Cortex; Primary Motor Cortex; Primary Somatosensory Cortex; Retrosplenial Dysgranular Cortex; Secondary Motor Cortex; Secondary Somatosensory Cortex; Temporal Association Cortex, Thalamus; Ventral Orbital Cortex; and Visual Cortex.”
Keywords
Alzheimer’s disease, Phenotyping, Animal model, Early-onset AD, MODEL-AD
Author Affiliation(s)
Indiana University School of Medicine, Indianapolis, Indiana, USA
