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Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-beta degrading proteases in human serum: a role in Alzheimer’s disease? J Alzheimers Dis. January 2012;29(2):329-340.

Full Text – Open Access

Publication Date
January 2012

How Analyze was Used
“All Images were analyzed using image analysis software (AnalyzeDirect, Inc. Overland, KS) by trained readers/analysts who were blinded to the subjects’ clinical status and under the supervision of a board-certified neuroradiologist…[Scott et al. 2004].”

Keywords
Aged
Aged, 80 and over
Alzheimer Disease/blood/genetics
Amyloid beta-Peptides/blood
Apolipoprotein E4/genetics
Brain/pathology
Female
Fluorescent Dyes/metabolism
Humans
Insulysin/blood
Islet Amyloid Polypeptide/blood
Magnetic Resonance Imaging (MRI)
Male
Mild Cognitive Impairment/blood/genetics
Neuropsychological Tests
Peptide Fragments/blood
Peptidyl-Dipeptidase A/blood
Psychiatric Status Rating Scales
Serum/enzymology
Statistics, Nonparametric
Time Factors

Author Affiliation(s)
Departments of Pharmacology and Experimental Therapeutics, Boston University Medical Campus, Boston, MA, US. (ZL, HZ, GGF, KW, BW, TI, WQQ)

Departments of Psychiatry, Boston University Medical Campus, Boston, MA, US. (WQQ)

Departments of Neurology, Boston University Medical Campus, Boston, MA, US. (BW, TI)

Department of Public Health and Family Medicine, Tufts University, Boston, MA, US. (MM)

Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, US. (SOAH, MAL)

Departments of Anesthesiology, The Second People’s Hospital of Shenzhen, Guandong Province, PR China. (ZL)

Departments of Gynecology, The Second People’s Hospital of Shenzhen, Guandong Province, PR China. (GGF)

ID# 591

Tags: Aged, Aged_80 and over, Alzheimer Disease/blood/genetics, Amyloid beta-Peptides/blood, Apolipoprotein E4/genetics, Brain/pathology, Female, Fluorescent Dyes/metabolism, Humans, Insulysin/blood, Islet Amyloid Polypeptide/blood, Magnetic Resonance Imaging (MRI), Male, Mild Cognitive Impairment/blood/genetics, Neuropsychological Tests, Nonparametric Statistics, Peptide Fragments/blood, Peptidyl-Dipeptidase A/blood, Psychiatric Status Rating Scales, Serum/enzymology, Time Factors