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Cerebral microglial activation in patients with hepatitis C: in vivo evidence of neuroinflammation

Grover VPB, Pavese N, Koh SB, Wylezinska M, Saxby BK, Gerhard A, Forton DM, Brooks DJ, Thomas HC, Taylor-Robinson SD. Cerebral microglial activation in patients with hepatitis C: in vivo evidence of neuroinflammation. J Viral Hepat. February 2012;19(2):e89-96.

Publication Date
February 2012

How Analyze was Used
“Striatal ROIs including whole striatum, caudate, putamen, pallidum, and thalamus were defined on individual MRI. BP [binding potential] values were extracted using ANALYZE software (Analyze AVW…) by applying ROIs onto the parametric images.”

Keywords
Adult
Aged
Brain/immunology/pathology/radiography/virology
Female
Hepatitis C, Chronic/immunology/pathology
Humans
Magnetic Resonance Spectroscopy
Male
Microglia/immunology/virology
Middle Aged

Author Affiliation(s)
Liver Unit, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK. (VPBG, HCT, SDTR)

Robert Steiner MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, London, UK. (VPBG, MW)

Neuroscience Section, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK. (NP, SBK, DJB)

Department of Neurology, Korea University, College of Medicine, Guro Hospital, South Korea. (SBK)

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK. (BKS)

Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. (AG)

Department of Gastroenterology and Hepatology, St George’s Hospital and Medical School, London, UK. (DMF)

ID# 931

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