AnalyzeDirect Gupta N, Saleem A, Kötz B, Osman S, Aboagye EO, Phillips R, Vernon C, Wasan H, Jones T, Hoskin PJ, Price PM. Carbogen and nicotinamide increase blood flow and 5-fluorouracil delivery but not 5-fluorouracil retention in colorectal cancer metastases in patients. Clin Cancer Res. May 2006;12(10):3115-3123.
Full Text – Open Access
Publication Date
May 2006
How Analyze was Used
“Reconstructed PET images were analyzed and regions of interest (ROI) drawn using a recent computed tomography scan to assist delineation of tumor and normal tissue areas. ROIs were defined using ANALYZE image analysis software … on summated images rather than individual time frames.”
Keywords
Administration, Inhalation
Administration, Oral
Aged
Antimetabolites, Antineoplastic/pharmacokinetics
Carbon Dioxide/pharmacology
Colorectal Neoplasms/drug therapy/pathology
Drug Interactions
Female
Fluorouracil/pharmacokinetics
Humans
Liver Neoplasms/drug therapy/secondary
Male
Middle Aged
Niacinamide/pharmacology
Oxygen/pharmacology
Radiation-Sensitizing Agents/pharmacology
Regional Blood Flow
Tissue Distribution
Vitamin B Complex/pharmacology
Author Affiliation(s)
Cancer Research UK PET Oncology Group and Hammersmith Imanet, Hammersmith Hospital NHS Trust, London, UK. (NG, AS, SO, EOA, RP, CV, HW, TJ, PMP)
Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. (BK)
Mount Vernon Hospital, Northwood, Middlesex, UK. (PJH)
ID# 1912
Tags: Aged, Antineoplastic Antimetabolites/pharmacokinetics, Carbon Dioxide/pharmacology, Colorectal Neoplasms/drug therapy/pathology, Drug Interactions, Female, Fluorouracil/pharmacokinetics, Humans, Inhalation Administration, Liver Neoplasms/drug therapy/secondary, Male, Middle Aged, Niacinamide/pharmacology, Oral Administration, Oxygen/pharmacology, Radiation-Sensitizing Agents/pharmacology, Regional Blood Flow, Tissue Distribution, Vitamin B Complex/pharmacology