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Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment

Sargent PA, Kjaer KH, Bench CJ, Rabiner EA, Messa C, Meyer J, Gunn RN, Grasby PM, Cowen PJ. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch Gen Psychiatry. February 2000;57(2):174-180.

Full Text – Open Access

Publication Date
February 2000

How Analyze was Used
“Regions of interest (ROIs) were defined using image analysis software (Analyze AVW v2.5).”

Keywords
Adult
Aged
Antidepressive Agents/pharmacology/therapeutic use
Brain/drug effects/metabolism/radionuclide imaging
Carbon Radioisotopes/diagnostic use
Depressive Disorder/drug therapy/metabolism/radionuclide imaging
Female
Frontal Lobe/metabolism/radionuclide imaging
Humans
Limbic System/metabolism/radionuclide imaging
Male
Middle Aged
Piperazines/diagnostic use
Pyridines/diagnostic use
Raphe Nuclei/metabolism/radionuclide imaging
Receptors, Serotonin/drug effects/metabolism
Temporal Lobe/metabolism/radionuclide imaging
Tomography, Emission-Computed/statistics & numerical data

Author Affiliation(s)
Medical Research Council Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, London, England, UK. (PAS, CJB, EAR, CM, JM, RNG, PMG, KHK)

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England, UK. (PAS, PJC)

Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark. (KHK)

Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK. (CJB, EAR, PMG)

University of Milan, Instituto Neuroscienze Bioimmagini–Consiglio Nazionale Ricerche, Institute H. S. Raffaele, Milan, Italy. (CM)

Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. (JM)

ID# 2845

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