AnalyzeDirect

Talbot PS, Bradley S, Clarke CP, Babalola KO, Philipp AW, Brown G, McMahon AW, Matthews JC. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using ¹¹C-DASB in healthy humans. Neuropsychopharmacology. February 2010;35(3):741-751.

Full Text – Open Access

Publication Date
February 2010

How Analyze was Used
“The region of reference (ROR) was manually delineated on the MRI, using Analyze…, in posterior cerebellar cortex, excluding vermis and central white matter and keeping at least one FWHM [full-width-at-half-maximum] from venous sinuses and occipital cortex (Meyer, 2007).”

Keywords
Administration, Oral
Adult
Benzylamines/diagnostic use
Brain/drug effects/metabolism/radionuclide imaging
Carbon Radioisotopes/diagnostic use
Cohort Studies
Cross-Over Studies
Cyclobutanes/administration & dosage/metabolism
Double-Blind Method
Humans
Male
Middle Aged
Positron-Emission Tomography (PET)/methods
Serotonin Plasma Membrane Transport Proteins/metabolism

Author Affiliation(s)
Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, UK. (PST)

Icon Development Solutions, Manchester, UK. (SB, CPC, AWP)

Manchester Academic Health Science Centre, Stopford Building, The University of Manchester, Manchester, UK. (KOB)

Manchester Academic Health Science Centre, Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, UK. (GB, AWM, JCM)

ID# 1404

Tags: Administration, Adult, Benzylamines/diagnostic use, Brain/drug effects/metabolism/radionuclide imaging, Carbon Radioisotopes/diagnostic use, Cohort Studies, Cross-Over Studies, Cyclobutanes/administration & dosage/metabolism, Double-Blind Method, Humans, Male, Middle Aged, Oral, Positron-Emission Tomography (PET)/methods, Serotonin Plasma Membrane Transport Proteins/metabolism