AnalyzeDirect Kate MP, Hansen MB, Mouridsen K, Østergaard L, Choi V, Gould BE, McCourt R, Hill MD, Demchuk AM, Coutts SB, Dowlatshahi D, Emery DJ, Buck BH, Butcher KS. Blood pressure reduction does not reduce perihematoma oxygenation: a CT perfusion study. J Cereb Blood Flow Metab. January 2014;34(1):81-86.
Full Text – Open Access
Publication Date
January 2014
How Analyze was Used
“Postprocessed perfusion and oxygenation maps underwent region of interest (ROI) analysis using Analyze 11.0 software package (… Overland Park, KS, USA). The hematoma perimeter was determined on the precontrast arrival CT source image using a semi-automated intensity threshold technique. The perihematoma ROI was drawn 1 cm away from the hematoma, as previously described. The perihematoma ROI was also reflected onto the contralateral hemisphere. All voxels containing blood vessels (CBF >100 mL/100 g per minute or CBV >8 mL/100 g) were removed from the ROI using an intensity threshold function. Mean CBF, CBV, OEFmax and CMRO2max were assessed in the perihematoma region and the contralateral homologous region.”
Keywords
Aged
Antihypertensive Agents/administration & dosage/therapeutic use
Blood Pressure/drug effects
Cerebral Hemorrhage/complications/drug therapy/physiopathology/radiography
Female
Hematoma/drug therapy/etiology/metabolism/radiography
Humans
Hydralazine/administration & dosage/therapeutic use
Labetalol/administration & dosage/therapeutic use
Male
Oxygen Consumption/drug effects
Tomography, X-Ray Computed/methods
Treatment Outcome
Author Affiliation(s)
Division of Neurology, Department of Medicine, WMC Health Sciences Centre, Edmonton, Alberta, Canada. (MPK, VC, BEG, RM, BHB, KSB)
Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark. (MBH, LØ)
Department of Clinical Neurosciences University of Calgary, Calgary, Alberta, Canada. (KM, MDH, AMD, SBC)
Division of Neurology, University of Ottawa, Ottawa, Ontario, Canada. (DD)
Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. (DJE)
ID# 359
Tags: Aged, Antihypertensive Agents/administration & dosage/therapeutic use, Blood Pressure/drug effects, Cerebral Hemorrhage/complications/drug therapy/physiopathology/radiography, Female, Hematoma/drug therapy/etiology/metabolism/radiography, Humans, Hydralazine/administration & dosage/therapeutic use, Labetalol/administration & dosage/therapeutic use, Male, Oxygen Consumption/drug effects, Treatment Outcome, X-Ray Computed Tomography/methods