AnalyzeDirect Frodl T, Schüle C, Schmitt G, Born C, Baghai T, Zill P, Bottlender R, Rupprecht R, Bondy B, Reiser M, Möller HJ, Meisenzahl EM. Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry. April 2007;64(4):410-416.
Full Text – Open Access
Publication Date
April 2007
How Analyze was Used
“A commercial software package was used for further image processing (Analyze …), with size reduction from 16 to 8 bits and transformation to a uniform matrix of 256 × 256 pixels on 192 sections of 1.0-mm thickness.”
Keywords
Adult
Amygdala/pathology
Atrophy
Brain-Derived Neurotrophic Factor/genetics
Cross-Sectional Studies
Depressive Disorder, Major/genetics/pathology
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Hippocampus/pathology
Humans
Magnetic Resonance Imaging (MRI)/statistics & numerical data
Male
Methionine/genetics
Neuronal Plasticity/genetics
Polymorphism, Genetic
Valine/genetics
Author Affiliation(s)
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Munich, Germany. (TF, CS, GS, TB, PZ , RR, BB, H-JM, EMM)
Department of Radiology, Ludwig-Maximilians University, Munich, Germany. (CB, MR)
East London and the City Mental Health NHS Trust, Department of Psychiatry, Newham Centre for Mental Health, London, UK. (RB).
ID# 1722
Tags: Adult, Amygdala/pathology, Atrophy, Brain-Derived Neurotrophic Factor/genetics, Cross Sectional Studies, Female, Gene Frequency, Genetic Polymorphism, Genetic Predisposition to Disease, Genotype, Hippocampus/pathology, Humans, Magnetic Resonance Imaging (MRI)/statistics & numerical data, Major Depressive Disorder/genetics/pathology, Male, Methionine/genetics, Neuronal Plasticity/genetics, Valine/genetics