AnalyzeDirect Fabbrini E, Cella M, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, Klein S. Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology. August 2013;145(2):366-374.e361-363.
Full Text – Open Access
Publication Date
August 2013
How Analyze was Used
“Intra-abdominal adipose tissue volume was quantified by magnetic resonance imaging (Siemens…; ANALYZE 7.0 software…), and intrahepatic triglyceride content was determined by using proton magnetic resonance spectroscopy.”
Keywords
Adult
Animals
Body Mass Index
CD4-Positive T-Lymphocytes/immunology/secretion
Case-Control Studies
Cytokines/immunology
Fat Free Mass
Female
Glucose/metabolism
Glucose Clamp Technique
Glucose Infusion Rate
Hepatocytes/drug effects
Humans
Insulin Resistance/immunology
Interferon
Interleukin-17/pharmacology/secretion
Interleukin-6/blood
Interleukins/blood/pharmacology/secretion
Liver/metabolism
Lymphocytes
Male
Metabolically Abnormal Insulin-Resistant Obese
Metabolically Abnormal Obesity
Metabolically Normal Insulin-Sensitive Obese
Metabolically Normal Obesity
Middle Aged
Muscle, Skeletal/drug effects/metabolism
Nonalcoholic Fatty Liver Disease
Obesity/immunology/metabolism
Rats
Receptors, Interleukin/metabolism
Receptors, Interleukin-17/metabolism
Subcutaneous Fat/immunology
T-Lymphocyte Subsets/immunology/secretion
Th17 Cells/immunology/secretion
Author Affiliation(s)
Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, US. (EF, NAA, TAP, ZC, BNF, DHH, FM, DB, GF, JCE, BWP, SK)
Center for Clinical and Basic Research, Department of Medical Sciences, IRCCS San Raffaele, Rome, Italy. (EF)
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, US. (MC, SAM, AF)
Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy. (CC, MC)
Department of Endocrinology and Metabolism, University Campus Bio-Medico, Rome, Italy. (GF)
ID# 265
Tags: Adult, Animals, Body Mass Index, Case-Control Studies, CD4-Positive T-Lymphocytes/immunology/secretion, Cytokines/immunology, Fat Free Mass, Female, Glucose Clamp Technique, Glucose Infusion Rate, Glucose/metabolism, Hepatocytes/drug effects, Humans, Insulin Resistance/immunology, Interferon, Interleukin Receptors/metabolism, Interleukin-17 Receptors/metabolism, Interleukin-17/pharmacology/secretion, Interleukin-6/blood, Interleukins/blood/pharmacology/secretion, Liver/metabolism, Lymphocytes, Male, Metabolically Abnormal Insulin-Resistant Obese, Metabolically Abnormal Obesity, Metabolically Normal Insulin-Sensitive Obese, Metabolically Normal Obesity, Middle Aged, Nonalcoholic Fatty Liver Disease, Obesity/immunology/metabolism, Rats, Skeletal Muscle /drug effects/metabolism, Subcutaneous Fat/immunology, T-Lymphocyte Subsets/immunology/secretion, Th17 Cells/immunology/secretion