AnalyzeDirect Kristen D. Onos et al. Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction Alzheimer’s & Dementia.
Publication Date
May 7, 2024
How Analyze was Used
“All PET, CT, and MRI images were co-registered using a ridged-body mutual information-based normalized entropy algorithm40 with 9 degrees of freedom and mapped to stereotactic mouse brain coordinates41 using Analyze 12 (AnalyzeDirect, Stilwell KS) and MIM Encore Software 7.3.2 (Beachwood OH). Imaging Study data was collected and managed using RedCap electronic data capture tools hosted at Indiana University. Post-registration, 56 regions bilateral regions were extracted via brain atlas and left/right averaged to yield 27 unique volumes of interest that map to key cognitive and motor centers.”
Keywords
Alzheimer’s disease, APOE, Metabolism, Perfusion, Uncoupling
Author Affiliation(s)
Indiana University School of Medicine, Indianapolis, Indiana, USA
