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Bauer M, Karch R, Zeitlinger M, Philippe C, Römermann K, Stanek J, Maier-Salamon A, Wadsak W, Jäger W, Hacker M, Müller M, Langer O. Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[¹¹C]verapamil PET study. J Cereb Blood Flow Metab. February 2015.

Full Text – Open Access

Publication Date
February 2015

How Analyze was Used
“The PET and magnetic resonance data were processed with Analyze 8.0 … and SPM5 … software and whole-brain gray matter time-activity curves were extracted using the Hammersmith n30r83 three-dimensional maximum probability atlas of the human brain as described previously [Langer et al. 2007].”

Keywords
Blood–Brain Barrier
P-Glycoprotein
Pituitary Gland
Positron Emission Tomography (PET)
(R)-[¹¹C]verapamil
Tariquidar

Author Affiliation(s)
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. (MB, MZ, KR, JS, MM, OL)

Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria. (RK)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. (CP, WW, MH)

Department of Pharmacology, Toxicology and Pharmacy, Center for Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany. (KR)

5Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria. (JS, OL)

Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria. (AMS, WJ)

Medical Imaging Cluster, Medical University of Vienna, Vienna, Austria. (WW, MH, OL)

ID# 1731

Tags: (R)-[11C]verapamil, Blood-Brain Barrier, P-Glycoprotein, Pituitary Gland, Positron Emission Tomography (PET), Tariquidar