AnalyzeDirect Bonnet CS, Williams AS, Gilbert SJ, Harvey AK, Evans BA, Mason DJ. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Ann Rheum Dis. October 2013.
Full Text – Open Access
Publication Date
October 2013
How Analyze was Used
“For MRI, both knees (six AIA, six AIA+NBQX) were imaged (Bruker Biospin Advance 9.4 T (400 mHz) system), transmit-receive quadrature coil, RARE-MRI sequence: TE=1250 ms, TR=24 ms, FA=180°, matrix size=580×280×280, FOV=58×28×28 mm) and 3D datasets manipulated to obtain representative mid-sagittal planes of each knee (Analyze 10.0).”
Keywords
AMPA Receptors/antagonists & inhibitors/immunology/metabolism
Animal Behavior/drug effects
Animals
Articular Cartilage/metabolism/radiography
Excitatory Amino Acid Antagonists/pharmacology
Experimental Arthritis/metabolism/radiography
Humans
Immunohistochemistry
Inflammation/metabolism
Interleukin-6/metabolism
Kainic Acid Receptors/antagonists & inhibitors/immunology/metabolism
Knee Joint/radiography
Male
Osteoarthritis/immunology/metabolism
Osteoblasts
Pain/immunology/metabolism
Quinoxalines/pharmacology
Rats
Rheumatoid Arthritis/immunology/metabolism
Synovial Membrane/drug effects/immunology/metabolism
Tibial Menisci/metabolism
Author Affiliation(s)
Arthritis Research UK Biomechanics and Bioengineering Centre, School of Biosciences, Cardiff University, Cardiff, UK. (CSB, SJG)
Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK. (ASW)
Arthritis Research UK Biomechanics and Bioengineering Centre, School of Medicine, Cardiff University, Cardiff, UK. (AKH)
Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Cardiff, UK. (BAE)
Division of Pathophysiology and Repair, School of Biosciences, Cardiff University, Cardiff, UK. (DJM)
ID# 357
Tags: AMPA Receptors/antagonists & inhibitors/immunology/metabolism, Animal Behavior/drug effects, Animals, Articular Cartilage/metabolism/radiography, Excitatory Amino Acid Antagonists/pharmacology, Experimental Arthritis/metabolism/radiography, Humans, Immunohistochemistry, Inflammation/metabolism, Interleukin-6/metabolism, Kainic Acid Receptors/antagonists & inhibitors/immunology/metabolism, Knee Joint/radiography, Male, Osteoarthritis/immunology/metabolism, Osteoblasts, Pain/immunology/metabolism, Quinoxalines/pharmacology, Rats, Rheumatoid Arthritis/immunology/metabolism, Synovial Membrane/drug effects/immunology/metabolism, Tibial Menisci/metabolism