AnalyzeDirect del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U. A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment. Brain. November 2013;136(Pt 11):3252-3270.
Full Text – Open Access
Publication Date
November 2013
How Analyze was Used
“For each subject, regions of interest were manually drawn on coronal planes of the MRAC-PC with Analyze 7.0 (AnalyzeDirect) as previously described (Mawlawi et al., 2001; Martinez et al., 2003; Del Campo et al., 2011b). The following striatal subregions were defined bilaterally: ventral striatum, pre-commissural dorsal putamen, pre-commissural dorsal caudate, post-commissural putamen and post-commissural caudate (Fig. 2).”
Keywords
18F-fallypride PET
Adult
Attention Deficit Disorder with Hyperactivity/drug therapy/metabolism/pathology/physiopathology
Benzamides/diagnostic use
Corpus Striatum/drug effects/metabolism/pathology/physiopathology
Cross-Over Studies
Dopamine
Dopamine Uptake Inhibitors/administration & dosage/pharmacology
Double-Blind Method
Fluorodeoxyglucose F18/diagnostic use
Humans
Magnetic Resonance Imaging (MRI) /instrumentation/methods
Male
Mesencephalon/drug effects/metabolism/pathology/physiopathology
Methylphenidate/administration & dosage/pharmacology
Multimodal Imaging/instrumentation/methods
Positron-Emission Tomography (PET)/instrumentation/methods
Psychiatric Status Rating Scales
Radiopharmaceuticals/diagnostic use
Sustained Attention
Young Adult
Author Affiliation(s)
Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK. (NdC, SRC, JD, JS, BJS, UM)
Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK. (NdC, SRC, RT, JS, TWR, BJS, UM)
Wolfson Brain Imaging Centre, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK. (TDF, YTH, RS, LR, JAC, DI)
Department of Clinical Neurosciences, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK. (TDF, YTH, RS, LB, JAC, JCB, FIA)
German Centre for Neurodegenerative Diseases, 39120 Magdeburg, Germany. (JAC, FIA)
Adult ADHD Service, Cambridgeshire and Peterborough NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK. (SRC, BJS, UM)
Department of Clinical Pharmacology, University of Leipzig, 04107 Leipzig, Germany. (RR)
Inserm U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris 75014, France. (JCB)
ID# 251
Tags: 18F-fallypride PET, Adult, Attention Deficit Disorder with Hyperactivity/drug therapy/metabolism/pathology/physiopathology, Benzamides/diagnostic use, Corpus Striatum/drug effects/metabolism/pathology/physiopathology, Cross-Over Studies, Dopamine, Dopamine Uptake Inhibitors/administration & dosage/pharmacology, Double-Blind Method, Fluorodeoxyglucose F18/diagnostic use, Humans, Magnetic Resonance Imaging (MRI) /instrumentation/methods, Male, Mesencephalon/drug effects/metabolism/pathology/physiopathology, Methylphenidate/administration & dosage/pharmacology, Multimodal Imaging/instrumentation/methods, Positron-Emission Tomography (PET)/instrumentation/methods, Psychiatric Status Rating Scales, Radiopharmaceuticals/diagnostic use, Sustained Attention, Young Adult