AnalyzeDirect Wagner CC, Bauer M, Karch R, Feurstein T, Kopp S, Chiba P, Kletter K, Löscher W, Müller M, Zeitlinger M, Langer O. A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET. J Nucl Med. December 2009;50(12):1954-1961.
Full Text – Open Access
Publication Date
December 2009
How Analyze was Used
“MRI and PET data were processed with Analyze 8.0 … and SPM5 … software as published previously [Langer et al, 2007].”
Keywords
Adult
Blood-Brain Barrier/drug effects/metabolism/radionuclide imaging
Carbon Radioisotopes/chemistry
Humans
Kinetics
Male
P-Glycoprotein/antagonists & inhibitors/metabolism
Pilot Projects
Positron-Emission Tomography (PET)
Quinolines/pharmacology
Verapamil/chemistry/metabolism
Author Affiliation(s)
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. (CCW, MB, TF, MM, MZ, OL)
Department of Medical Computer Sciences, Medical University of Vienna, Vienna, Austria. (RK)
Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria. (SK, PC)
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. (KK)
Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany. (WL)
Molecular Medicine, Austrian Institute of Technology GmbH, Seibersdorf, Austria. (OL)
ID# 1338
Tags: Adult, Blood-Brain Barrier/drug effects/metabolism/radionuclide imaging, Carbon Radioisotopes/chemistry, Humans, Kinetics, Male, P-Glycoprotein/antagonists & inhibitors/metabolism, Pilot Projects, Positron Emission Tomography (PET), Quinolines/pharmacology, Verapamil/chemistry/metabolism