Young Jong Ko et al. A novel modified RANKL variant can prevent osteoporosis by acting as a vaccine and an inhibitor Clinical and Translational Medicine.
March 17, 2021
How Analyze was Used
“Micro‐CT scanning of the distal femur was distally initiated at the level of growth plate using a Quantum GX (PerkinElmer, Hopkinton, MA, USA) micro‐CT imaging system located at the Korea Basic Science Institute in Gwangju, Korea. The scanning X‐ray source was set to 88 mA and 90 kV, with a 10 mm field of view (scanning time, 4 min; voxel size, 20 μm). The 3D architecture images were acquired using 3D Viewer commercial software included with the Quantum GX system. The 3D images were obtained at 4.5 μm resolution. After scanning, the bone structure parameters were analyzed with Analyze 12.0 software (AnalyzeDirect, Overland Park, KS, USA) using the ROI tool. Femur bone mineral density was estimated using hydroxyapatite (HA) Phantom (QRM‐MicroCT‐HA, Quality Assurance in Radiology and Medicine GmbH, Germany) scanning using the same parameters. Parameter values are shown as mean ± standard deviation (SD).”
Immunotherapy, LGR4, Osteoclastogenesis, RANK
Chosun University Hospital, Dong‐Gu Gwangju, Republic of Korea