AnalyzeDirect Loesch DZ, Cook M, Litewka L, Gould E, Churchyard A, Tassone F, Slater HR, Storey E. A low symptomatic form of neurodegeneration in younger carriers of the FMR1 premutation, manifesting typical radiological changes. J Med Genet. March 2008;45(3):179-181.
Publication Date
March 2008
How Analyze was Used
“Volumetric analysis was performed on a UNIX workstation using Analyze AVW … Using the region of interest (ROI) module of Analyze AVW, the measurements were performed using manually traced boundaries (or regions-of-interest) based on predetermined structural landmarks for sequential MRI slices.”
Keywords
Adult
Ataxia/genetics
Cerebellar Diseases/genetics/pathology/psychology
Fragile X Mental Retardation Protein/genetics
Fragile X Syndrome/genetics/pathology/psychology
Heredodegenerative Disorders, Nervous System/genetics/pathology/psychology
Humans
Magnetic Resonance Imaging (MRI)
Male
Middle Aged
Mutation
Tremor/genetics
Trinucleotide Repeat Expansion
Author Affiliation(s)
School of Psychological Science, La Trobe University, Victoria, Australia. (DZL, EG)
Department of Clinical Neuroscience and Neurological Research, St Vincent’s Hospital & University of Melbourne, Victoria, Australia. (MC, LL)
Southern Health Network, Victoria, Australia. (AC)
Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, CA, US. (FT)
VCGS Cytogenetics Laboratory, Murdoch Children’s Research Institute, Royal Children’s Hospital, Victoria, Australia. (HRS)
Van Cleef Roet Centre for Nervous Diseases, Monash University (Alfred Hospital Campus), Victoria, Australia. (ES)
ID# 1616
Tags: Adult, Ataxia/genetics, Cerebellar Diseases/genetics/pathology/psychology, Fragile X Mental Retardation Protein/genetics, Fragile X Syndrome/genetics/pathology/psychology, Humans, Magnetic Resonance Imaging (MRI), Male, Middle Aged, Mutation, Nervous System Heredodegenerative Disorders/genetics/pathology/psychology, Tremor/genetics, Trinucleotide Repeat Expansion