AnalyzeDirect Lingford-Hughes A, Reid AG, Myers J, Feeney A, Hammers A, Taylor LG, Rosso L, Turkheimer F, Brooks DJ, Grasby P, Nutt DJ. A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced alpha5 benzodiazepine receptors in limbic regions. J Psychopharmacol. February 2012;26(2):273-281.
Publication Date
February 2012
How Analyze was Used
“Reconstructed [11C]Ro15 4513 images were analysed on a Sun SPARC workstation … using Analyze AVW version 8.1.”
Keywords
Adult
Alcoholism/metabolism/radionuclide imaging
Azides/diagnostic use/pharmacokinetics
Benzodiazepines/diagnostic use/pharmacokinetics
Carbon Radioisotopes/diagnostic use
Case-Control Studies
Ethanol/metabolism/poisoning
Humans
Limbic System/drug effects/metabolism/radionuclide imaging
Male
Memory/drug effects
Nucleus Accumbens/drug effects/metabolism/radionuclide imaging
Positron-Emission Tomography/methods
Receptors, GABA-A/metabolism
Author Affiliation(s)
Psychopharmacology Unit, Dorothy Hodgkin Building, University of Bristol, Bristol, UK. (ALH, AGR, JM, AF, LGT, DJN)
MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK. (ALH, AGR, JM, AF, AH, LR, FT, DJB, PG)
University Hospitals Bristol NHS Foundation Trust, Bristol, UK. (LGT)
Hammersmith Imanet Ltd, Hammersmith Hospital, London, UK. (DJB)
ID# 460
Tags: Adult, Alcoholism/metabolism/radionuclide imaging, Azides/diagnostic use/pharmacokinetics, Benzodiazepines/diagnostic use/pharmacokinetics, Carbon Radioisotopes/diagnostic use, Case-Control Studies, Ethanol/metabolism/poisoning, GABA-A Receptors/metabolism, Humans, Limbic System/drug effects/metabolism/radionuclide imaging, Male, Memory/drug effects, Nucleus Accumbens/drug effects/metabolism/radionuclide imaging, Positron-Emission Tomography (PET)/methods