AnalyzeDirect Wilson SH, Herrmann J, Lerman LO, Holmes DR, Jr., Napoli C, Ritman EL, Lerman A. Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering. Circulation. January 2002;105(4):415-418.
Full Text – Open Access
Publication Date
January 2002
How Analyze was Used
“Data analysis was performed blinded to treatment using Analyze software.”
Keywords
Animals
Blotting, Western
Cholesterol/blood
Coronary Angiography
Coronary Vessels/drug effects/metabolism
Diet, Atherogenic
Endothelial Growth Factors/immunology/metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/therapeutic use
Hypercholesterolemia/blood/drug therapy/radiography
Hypoxia-Inducible Factor 1, alpha Subunit
Immunohistochemistry
Lymphokines/immunology/metabolism
Matrix Metalloproteinases/immunology/metabolism
Neovascularization, Pathologic/blood/drug therapy/radiography
Simvastatin/ pharmacology/therapeutic use
Swine
Tomography, X-Ray Computed
Transcription Factors/immunology/metabolism
Vasa Vasorum/drug effects/radiography
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Author Affiliation(s)
Divisions of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, US. (SHW, JH, DRH, AL)
Division of Hypertension, Mayo Clinic, Rochester, MN, US. (LOL)
Division of Physiology and Biophysics, Mayo Clinic, Rochester, MN, US. (ELR)
Department of Medicine, University of Naples, Italy. (CN)
Department of Medicine, University of California, San Diego, CA, US. (CN)
ID# 2507
Tags: Animals, Atherogenic Diet, Cholesterol/blood, Coronary Angiography, Coronary Vessels/drug effects/metabolism, Endothelial Growth Factors/immunology/metabolism, Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/therapeutic use, Hypercholesterolemia/blood/drug therapy/radiography, Hypoxia-Inducible Factor 1_alpha Subunit, Immunohistochemistry, Lymphokines/immunology/metabolism, Matrix Metalloproteinases/immunology/metabolism, Pathologic Neovascularization/blood/drug therapy/radiography, Simvastatin/ pharmacology/therapeutic use, Swine, Transcription Factors/immunology/metabolism, Vasa Vasorum/drug effects/radiography, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors, Western Blotting, X-Ray Computed Tomography