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Csernansky JG, Wang L, Swank J, Miller JP, Gado M, McKeel D, Miller MI, Morris JC. Preclinical detection of Alzheimer’s disease: hippocampal shape and volume predict dementia onset in the elderly. Neuroimage. April 2005;25(3):783-792.

Publication Date
April 2005

How Analyze was Used
“To create a template representation of the hippocampus in the template MR scan, the left and right hippocampi were manually outlined in this scan by the consensus of a team of experts (LW, MG, and DM) using Analyze-AVW software.”

Keywords
Aged
Aged, 80 and over
Alzheimer Disease/diagnosis
Dentate Gyrus/pathology
Dominance, Cerebral/physiology
Early Diagnosis
Female
Follow-Up Studies
Hippocampus/pathology
Humans
Image Enhancement
Image Processing, Computer-Assisted
Magnetic Resonance Imaging (MRI)
Male
Mathematical Computing
Middle Aged
Neuropsychological Tests
Organ Size
Predictive Value of Tests
Proportional Hazards Models
Reference Values
Risk Assessment

Author Affiliation(s)
Department of Psychiatry, Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, US. (JGC, LW)

Department of Anatomy and Neurobiology, Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, US. (JGC)

Department of Neurology, Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, US. (JC, JCM)

Division of Biostatistics, Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, US. (JPM)

Department of Radiology, Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, US. (MG)

Department of Pathology and Immunology, Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, US. (DM, JCM)

Center for Imaging Science, and the Whiting School of Engineering at Johns Hopkins University, Baltimore, MD 21218-2681, US. (MIM)

ID# 2152

Tags: Aged, Aged_80 and over, Alzheimer Disease/diagnosis, Cerebral Dominance/physiology, Computer-Assisted Image Processing, Dentate Gyrus/pathology, Early Diagnosis, Female, Follow-Up Studies, Hippocampus/pathology, Humans, Image Enhancement, Magnetic Resonance Imaging (MRI), Male, Mathematical Computing, Middle Aged, Neuropsychological Tests, Organ Size, Predictive Value of Tests, Proportional Hazards Models, Reference Values, Risk Assessment